Article
A major QTL on chromosome 11 influences psychostimulant and opioid sensitivity in mice.
Genes, brain, and behavior - 1 Nov 2009
Bryant C D, Chang H P, Zhang J, Wiltshire T, Tarantino L M, Palmer A A
Abstract excerpt
The identification of genes influencing sensitivity to stimulants and opioids is important for determining their mechanism of action and may provide fundamental insights into the genetics of drug abuse. We used a panel of C57BL/6J (B6; recipient)x A/J (donor) chromosome substitution strains (CSSs) to identify quantitative trait loci (QTL) for both open field activity and sensitivity to the locomotor stimulant...
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