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Article

Structural analysis of autoinhibition in the Ras activator Son of sevenless.

Cell - 29 Oct 2004

Sondermann Holger, Soisson Stephen M, Boykevisch Sean, Yang Shao-Song, Bar-Sagi Dafna, Kuriyan John

Abstract excerpt

The classical model for the activation of the nucleotide exchange factor Son of sevenless (SOS) involves its recruitment to the membrane, where it engages Ras. The recent discovery that Ras*GTP is an allosteric activator of SOS indicated that the regulation of SOS is more complex than originally envisaged. We now present crystallographic and biochemical analyses of a construct of SOS that contains the Dbl...

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Source

Identifiers

PMID: 15507210
DOI: 10.1016/j.cell.2004.10.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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