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Article

The Son of sevenless gene product: a putative activator of Ras.

Science (New York, N.Y.) - 31 Jan 1992

Bonfini L, Karlovich C A, Dasgupta C, Banerjee U

Abstract excerpt

The Son of sevenless (Sos) gene functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases. The Sos gene has now been isolated and sequenced. Its product is a 1595-amino acid protein similar to the CDC25 protein in Saccharomyces cerevisiae, a guanine nucleotide exchange factor that activates Ras. These results imply a role for the ras pathway in Drosophila...

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Identifiers

PMID: 1736363
DOI: 10.1126/science.1736363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Son of sevenless gene product: a putative activator of Ras.PMID 1736363Read ↗

Understanding SOS (Son of Sevenless).Semantic proximity Read ↗

Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases.Semantic proximity Read ↗

DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.Semantic proximity Read ↗

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.Semantic proximity Read ↗

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro.Semantic proximity Read ↗

New class of Son-of-sevenless (Sos) alleles highlights the complexities of Sos function.Semantic proximity Read ↗

Development of Noonan syndrome by deregulation of allosteric SOS autoactivation.Semantic proximity Read ↗

Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome.Semantic proximity Read ↗

Small molecule Son of Sevenless 1 (SOS1) inhibitors: a review of the patent literature.Semantic proximity Read ↗

Comparison of the sevenless genes of Drosophila virilis and Drosophila melanogaster.Semantic proximity Read ↗

STAR, a gene family involved in signal transduction and activation of RNA.Semantic proximity Read ↗

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways.Semantic proximity Read ↗

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