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Article

Molecular assemblies of the catalytic domain of SOS with KRas and oncogenic mutants.

Proceedings of the National Academy of Sciences of the United States of America - 23 Mar 2021

Moghadamchargari Zahra, Shirzadeh Mehdi, Liu Chang, Schrecke Samantha, Packianathan Charles, Russell David H, Zhao Minglei, Laganowsky Arthur

Abstract excerpt

Ras is regulated by a specific guanine nucleotide exchange factor Son of Sevenless (SOS), which facilitates the exchange of inactive, GDP-bound Ras with GTP. The catalytic activity of SOS is also allosterically modulated by an active Ras (Ras-GTP). However, it remains poorly understood how oncogenic Ras mutants interact with SOS and modulate its activity. Here, native ion mobility-mass spectrometry is employed to...

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Identifiers

PMID: 33723061
DOI: 10.1073/pnas.2022403118
PMCID: PMC8000204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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