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Article

Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism.

The Journal of biological chemistry - 16 Feb 2007

Murayama Kazutaka, Shirouzu Mikako, Kawasaki Yoshihiro, Kato-Murayama Miyuki, Hanawa-Suetsugu Kyoko, Sakamoto Ayako, Katsura Yasuhiro, Suenaga Atsushi, Toyama Mitsutoshi, Terada Takaho, Taiji Makoto, Akiyama Tetsu, Yokoyama Shigeyuki

Abstract excerpt

The Rac-specific guanine nucleotide exchange factor (GEF) Asef is activated by binding to the tumor suppressor adenomatous polyposis coli mutant, which is found in sporadic and familial colorectal tumors. This activated Asef is involved in the migration of colorectal tumor cells. The GEFs for Rho...

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Identifiers

PMID: 17190834
DOI: 10.1074/jbc.C600234200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17190834-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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