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Article

Structural insights into the activation of the RhoA GTPase by the lymphoid blast crisis (Lbc) oncoprotein.

The Journal of biological chemistry - 22 Aug 2014

Lenoir Marc, Sugawara Masae, Kaur Jaswant, Ball Linda J, Overduin Michael

Abstract excerpt

The small GTPase RhoA promotes deregulated signaling upon interaction with lymphoid blast crisis (Lbc), the oncogenic form of A-kinase anchoring protein 13 (AKAP13). The onco-Lbc protein is a hyperactive Rho-specific guanine nucleotide exchange factor (GEF), but its structural mechanism has not been reported despite its involvement in cardiac hypertrophy and cancer causation. The pleckstrin homology (PH) domain...

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Topics

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Share to A Kinase Anchor Proteins
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Minor Histocompatibility Antigens

Share to Nuclear Magnetic Resonance, Biomolecular

Share to Protein Conformation

Share to Proto-Oncogene Proteins

Share to rhoA GTP-Binding Protein

Source

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Identifiers

PMID: 24993829
DOI: 10.1074/jbc.M114.561787
PMCID: PMC4156082

Genes

AKAP13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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