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Article

Understanding SOS (Son of Sevenless).

Biochemical pharmacology - 1 Nov 2011

Pierre Stéphane, Bats Anne-Sophie, Coumoul Xavier

Abstract excerpt

Son of Sevenless (SOS) was discovered in Drosophila melanogaster. Essential for normal eye development in Drosophila, SOS has two human homologues, SOS1 and SOS2. The SOS1 gene encodes the Son of Sevenless 1 protein, a Ras and Rac guanine nucleotide exchange factor. This protein is composed of several important domains. The CDC25 and REM domains provide the catalytic activity of SOS1 towards Ras and the histone...

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Identifiers

PMID: 21787760
DOI: 10.1016/j.bcp.2011.07.072

Genes

SOS1
SOS2

Provenance

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Related research

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Research trail→

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Understanding SOS (Son of Sevenless).PMID 21787760Read ↗

The Son of sevenless gene product: a putative activator of Ras.Semantic proximity Read ↗

Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome.Semantic proximity Read ↗

Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases.Semantic proximity Read ↗

SOS GEFs in health and disease.Semantic proximity Read ↗

Development of Noonan syndrome by deregulation of allosteric SOS autoactivation.Semantic proximity Read ↗

New class of Son-of-sevenless (Sos) alleles highlights the complexities of Sos function.Semantic proximity Read ↗

Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome.Semantic proximity Read ↗

Ras-guanine nucleotide exchange factor sos2 is dispensable for mouse growth and development.Semantic proximity Read ↗

Differential allelic expression of SOS1 and hyperexpression of the activating SOS1 c.755C variant in a Noonan syndrome family.Semantic proximity Read ↗

DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.Semantic proximity Read ↗

Small molecule Son of Sevenless 1 (SOS1) inhibitors: a review of the patent literature.Semantic proximity Read ↗

Sobp modulates Six1 transcriptional activation and is required during craniofacial developmentSemantic proximity Read ↗

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