Article
The structural basis of the activation of Ras by Sos.
Nature - 23 Jul 1998
Boriack-Sjodin P A, Margarit S M, Bar-Sagi D, Kuriyan J
Abstract excerpt
The crystal structure of human H-Ras complexed with the Ras guanine-nucleotide-exchange-factor region of the Son of sevenless (Sos) protein has been determined at 2.8 A resolution. The normally tight interaction of nucleotides with Ras is disrupted by Sos in two ways. First, the insertion into Ra...
Topics
- Binding Sites
- Catalysis
- Cloning, Molecular
- Crystallography, X-Ray
- Escherichia coli
- GTP Phosphohydrolase-Linked Elongation Factors
- Guanine
- Guanosine Triphosphate
- Humans
- Membrane Proteins
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Peptide Elongation Factor Tu
- Peptide Elongation Factors
- Protein Binding
- Protein Conformation
- Son of Sevenless Proteins