Article
On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.
BMC structural biology - 21 May 2009
Zheng Meiying, Cierpicki Tomasz, Momotani Ko, Artamonov Mykhaylo V, Derewenda Urszula, Bushweller John H, Somlyo Avril V, Derewenda Zygmunt S
Abstract excerpt
BACKGROUND: The Dbl-family of guanine nucleotide exchange factors (GEFs) activate the cytosolic GTPases of the Rho family by enhancing the rate of exchange of GTP for GDP on the cognate GTPase. This catalytic activity resides in the DH (Dbl-homology) domain, but typically GEFs are multidomain proteins containing other modules. It is believed that GEFs are autoinhibited in the cytosol due to supramodular...
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