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Article

Development of Noonan syndrome by deregulation of allosteric SOS autoactivation.

The Journal of biological chemistry - 25 Sept 2020

Umutesi Hope Gloria, Hoang Hanh My, Johnson Hope Elizabeth, Nam Kwangho, Heo Jongyun

Abstract excerpt

Ras family proteins play an essential role in several cellular functions, including growth, differentiation, and survival. The mechanism of action of Ras mutants in Costello syndrome and cancers has been identified, but the contribution of Ras mutants to Noonan syndrome, a genetic disorder that prevents normal development in various parts of the body, is unknown. Son of Sevenless (SOS) is a Ras guanine nucleotide...

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Identifiers

PMID: 32753483
DOI: 10.1074/jbc.RA120.013275
PMCID: PMC7521655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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