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Article

New class of Son-of-sevenless (Sos) alleles highlights the complexities of Sos function.

Genesis (New York, N.Y. : 2000) - 1 Aug 2004

Silver Serena J, Chen Fangli, Doyon Laura, Zink Andrina Williams, Rebay Ilaria

Abstract excerpt

The guanine nucleotide exchange factor (GEF) Son-of-sevenless (Sos) encodes a complex multidomain protein best known for its role in activating the small GTPase RAS in response to receptor tyrosine kinase (RTK) stimulation. Much less well understood is SOS's role in modulating RAC activity via a separate GEF domain. In the course of a genetic modifier screen designed to investigate the complexities of RTK/RAS...

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Identifiers

PMID: 15286999
DOI: 10.1002/gene.20054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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New class of Son-of-sevenless (Sos) alleles highlights the complexities of Sos function.PMID 15286999Read ↗

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