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Article

A role for NF-kappa B subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2004

Gadjeva Mihaela, Tomczak Michal F, Zhang Ming, Wang Yan Yan, Dull Karen, Rogers Arlin B, Erdman Susan E, Fox James G, Carroll Michael, Horwitz Bruce H

Abstract excerpt

To evaluate the possibility that NF-kappaB subunits p50 and p65 have a role in limiting the systemic inflammatory response induced by endotoxin, we compared the susceptibility of wild-type (WT), p65+/-, p50-/-, and p50-/-p65+/- (3X) mice to LPS-induced shock. Interestingly, whereas p65+/- mice were no more sensitive than WT mice to LPS-induced shock, 3X mice were exquisitely sensitive to the toxic effects of LPS....

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Identifiers

PMID: 15494531
DOI: 10.4049/jimmunol.173.9.5786

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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