p50-NF-kappaB complexes partially compensate for the absence of RelB: severely increased pathology in p50(-/-)relB(-/-) double-knockout mice.

doi:10.1084/jem.185.7.1359

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Article

p50-NF-kappaB complexes partially compensate for the absence of RelB: severely increased pathology in p50(-/-)relB(-/-) double-knockout mice.

The Journal of experimental medicine - 7 Apr 1997

Weih F, Durham S K, Barton D S, Sha W C, Baltimore D, Bravo R

Abstract excerpt

RelB-deficient mice (relB(-/-)) have a complex phenotype including multiorgan inflammation and hematopoietic abnormalities. To examine whether other NF-kappaB/Rel family members are required for the development of this phenotype or have a compensatory role, we have initiated a program to generate...

Topics

Abnormalities, Multiple
Animals
Bone Marrow
Digestive System
Gene Expression Regulation
Inflammation
Lung
Lymphocytes
Lymphoid Tissue
Macrophages
Mice
Mice, Knockout

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myocardium

NF-kappa B

NF-kappa B p50 Subunit

Phenotype

Protein Binding

Proto-Oncogene Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 9104822
DOI: 10.1084/jem.185.7.1359
PMCID: PMC2196264

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9104822-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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