Article
Lipopolysaccharide-induced cytokine cascade and lethality in LT alpha/TNF alpha-deficient mice.
Molecular medicine (Cambridge, Mass.) - 1 Dec 1997
Amiot F, Fitting C, Tracey K J, Cavaillon J M, Dautry F
Abstract excerpt
BACKGROUND: Tumor necrosis factor alpha (TNF-alpha) is often considered the main proinflammatory cytokine induced by lipopolysaccharide (LPS) and consequently the critical mediator of the lethality associated with septic shock. MATERIALS AND METHODS: We used mice carrying a deletion of both the lymphotoxin alpha (LT-alpha) and TNF-alpha genes to assess the role of TNF in the cytokine cascade and lethality induced...
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