Lipopolysaccharide-induced cytokine cascade and lethality in LT alpha/TNF alpha-deficient mice.

Article

Lipopolysaccharide-induced cytokine cascade and lethality in LT alpha/TNF alpha-deficient mice.

Molecular medicine (Cambridge, Mass.) - 1 Dec 1997

Amiot F, Fitting C, Tracey K J, Cavaillon J M, Dautry F

Abstract excerpt

BACKGROUND: Tumor necrosis factor alpha (TNF-alpha) is often considered the main proinflammatory cytokine induced by lipopolysaccharide (LPS) and consequently the critical mediator of the lethality associated with septic shock. MATERIALS AND METHODS: We used mice carrying a deletion of both the l...

Topics

Animals
Cytokines
Genotype
Hydrazones
Interferon-gamma
Interleukins
Lipopolysaccharides
Lymphotoxin-alpha
Macrophages
Mice
Mice, Inbred C57BL
Mice, Knockout
Tumor Necrosis Factor-alpha

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