Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappaB abrogate fulminant septic shock induced by S. typhimurium in mice.

Scandinavian journal of immunology - 1 Oct 2001

Schlaak J F, Barreiros A P, Pettersson S, Schirmacher P, Meyer Zum Büschenfelde K H, Neurath M F

Abstract excerpt

The aim of this study was to characterize the functional relevance of the transcription factor NF-kappaB in the pathogenesis of septic shock. BALB/c mice were infected with two wild-type (WT 1, WT 2) strains of S. typhimurium that induce NF-kappaB or an escape variant that lacks this ability (P21) at a dose of 1 x 109/animal, respectively. Furthermore, wild-type infected mice were treated with antisense...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Pair Mismatch
Share to Fluorescein-5-isothiocyanate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oligodeoxyribonucleotides, Antisense

Share to Peptide Chain Initiation, Translational

Share to Salmonella Infections

Share to Shock, Septic

Share to Thionucleotides

Share to Transcription Factor RelA

Source

Identifiers

PMID: 11555406
DOI: 10.1046/j.1365-3083.2001.00986.x

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappaB abrogate fulminant septic shock induced by S. typhimurium in mice.PMID 11555406Read ↗

A role for NF-kappa B subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock.Semantic proximity Read ↗

Peptide nucleic acid antisense oligomer as a therapeutic strategy against bacterial infection: proof of principle using mouse intraperitoneal infection.Semantic proximity Read ↗

Virulence and vaccine potential of Salmonella typhimurium mutants deficient in the expression of the RpoS (sigma S) regulon.Semantic proximity Read ↗

Endotoxin Tolerance Disrupts Chromatin Remodeling and NF-κB Transactivation at the IL-1β PromoterSemantic proximity Read ↗

Autogenous suppression of an opal mutation in the gene encoding peptide chain release factor 2.Semantic proximity Read ↗

Immunostimulatory CpG Oligodeoxynucleotide Confers Protection in a Murine Model of Infection withBurkholderia pseudomalleiSemantic proximity Read ↗

c-Fos-deficient mice are susceptible to Salmonella enterica serovar Typhimurium infection.Semantic proximity Read ↗

Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-alpha and not by Fas ligand.Semantic proximity Read ↗

Gene deletion of NF-kappa B p50 does not alter the hepatic inflammatory response to ischemia/reperfusion.Semantic proximity Read ↗

Mitogen-activated protein kinases and tumor necrosis factor alpha responses of macrophages infected with Orientia tsutsugamushiSemantic proximity Read ↗

Immune responses in BALB/c mice following immunization with aromatic compound or purine-dependent Salmonella typhimurium strains.Semantic proximity Read ↗

Immune changes during acute cold/restraint stress-induced inhibition of host resistance to Listeria.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.