Article
Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses.
Cell - 27 Jan 1995
Sha W C, Liou H C, Tuomanen E I, Baltimore D
Abstract excerpt
NF-kappa B, a heterodimeric transcription factor composed of p50 and p65 subunits, can be activated in many cell types and is thought to regulate a wide variety of genes involved in immune function and development. Mice lacking the p50 subunit of NF-kappa B show no developmental abnormalities, bu...
Topics
- Animals
- B-Lymphocyte Subsets
- B-Lymphocytes
- Blotting, Northern
- Cells, Cultured
- Cytokines
- Flow Cytometry
- Gene Expression
- Genetic Predisposition to Disease
- Immunoglobulin Isotypes
- Interferon-beta
- Lipopolysaccharides
- Listeria monocytogenes
- Listeriosis
- Lymphocyte Activation
- Macromolecular Substances
- Macrophages, Peritoneal
- Mice