Article
Characterization of the cis-acting element directing perinuclear localization of the metallothionein-1 mRNA.
Biochemical Society transactions - 1 Nov 2004
Chabanon H, Nury D, Mickleburgh I, Burtle B, Hesketh J
Abstract excerpt
Subcellular localization of mRNAs is a key mechanism for the synthesis of proteins close to their site of function. The mRNA encoding MT-1 (metallothionein-1) is localized in the perinuclear cytoplasm, where it is associated with cytoskeletal-bound polysomes. This localization relies on sequences present in the 3'-UTR (3'-untranslated region). The present study aims to characterize the cis-acting localization...
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