Article
Functional characterization of the HuR:CD83 mRNA interaction.
PloS one - 1 Jan 2011
Pieper Dorothea, Schirmer Susann, Prechtel Alexander T, Kehlenbach Ralph H, Hauber Joachim, Chemnitz Jan
Abstract excerpt
Maturation of dendritic cells (DC) is characterized by expression of CD83, a surface protein that appears to be necessary for the effective activation of naïve T-cells and T-helper cells by DC. Lately it was shown that CD83 expression is regulated on the posttranscriptional level by interaction of the shuttle protein HuR with a novel posttranscriptional regulatory RNA element (PRE), which is located in the coding...
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