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Article

An eleven nucleotide section of the 3'-untranslated region is required for perinuclear localization of rat metallothionein-1 mRNA.

The Biochemical journal - 15 Apr 2005

Nury David, Chabanon Hervé, Levadoux-Martin Marilyne, Hesketh John

Abstract excerpt

Localization of mRNAs provides a novel mechanism for synthesis of proteins close to their site of function. MT1 (metallothionein-1) is a small, metal-binding protein that is largely cytoplasmic but which can be found in the nucleus. The localization of rat MT1 requires the perinuclear localization of its mRNA by a mechanism dependent on the 3'-UTR (3'-untranslated region). The present study investigates the...

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PMID: 15537387
DOI: 10.1042/BJ20040630
PMCID: PMC1134970

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