Defining a novel ribonucleotide reductase r1 mRNA cis element that binds to an unique cytoplasmic trans-acting protein.

doi:10.1093/nar/22.22.4796

Back to search

Article

Defining a novel ribonucleotide reductase r1 mRNA cis element that binds to an unique cytoplasmic trans-acting protein.

Nucleic acids research - 11 Nov 1994

Chen F Y, Amara F M, Wright J A

Abstract excerpt

Ribonucleotide reductase is a highly regulated rate-limiting enzyme activity in DNA synthesis, responsible for reducing ribonucleotides to their deoxyribonucleotide forms. Using 3'-end labeled RNA and band-shift and UV cross-linking analyses, we have identified a cis-element, 5'-CAAACUUC-3', with...

Topics

3T3 Cells
Animals
Base Sequence
Binding Sites
Binding, Competitive
Cytoplasm
Granulocyte-Macrophage Colony-Stimulating Factor
Mice
Molecular Sequence Data
Mutation
RNA Probes
RNA, Messenger
RNA-Binding Proteins
Ribonucleotide Reductases

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.