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Article

Defining a novel ribonucleotide reductase r1 mRNA cis element that binds to an unique cytoplasmic trans-acting protein.

Nucleic acids research - 11 Nov 1994

Chen F Y, Amara F M, Wright J A

Abstract excerpt

Ribonucleotide reductase is a highly regulated rate-limiting enzyme activity in DNA synthesis, responsible for reducing ribonucleotides to their deoxyribonucleotide forms. Using 3'-end labeled RNA and band-shift and UV cross-linking analyses, we have identified a cis-element, 5'-CAAACUUC-3', within the 3'-untranslated region of the mammalian ribonucleotide reductase R1 mRNA, which binds a cytoplasmic protein in...

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Identifiers

PMID: 7984431
DOI: 10.1093/nar/22.22.4796
PMCID: PMC308532

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