Article
A localisation signal in the 3' untranslated region of c-myc mRNA targets c-myc mRNA and beta-globin reporter sequences to the perinuclear cytoplasm and cytoskeletal-bound polysomes.
Journal of cell science - 1 Jun 1996
Veyrune J L, Campbell G P, Wiseman J, Blanchard J M, Hesketh J E
Abstract excerpt
There is increasing evidence that in mammalian cells some mRNAs are localised to specific parts of the cytoplasm and a proportion of mRNAs and polyribosomes are associated with the cytoskeleton. It has been shown previously that c-myc mRNA is present in the perinuclear cytoplasm and associated wi...
Topics
- Animals
- Base Sequence
- Cells, Cultured
- Cytoplasm
- Cytoskeleton
- Genes, Reporter
- Genes, myc
- Globins
- In Situ Hybridization
- Mutation
- Polyribosomes
- Protein Biosynthesis
