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Article

Upstream open reading frame in 5'-untranslated region reduces titin mRNA translational efficiency.

Biochemical and biophysical research communications - 10 Oct 2014

Cadar Adrian G, Zhong Lin, Lin Angel, Valenzuela Mauricio O, Lim Chee C

Abstract excerpt

Titin is the largest known protein and a critical determinant of myofibril elasticity and sarcomere structure in striated muscle. Accumulating evidence that mRNA transcripts are post-transcriptionally regulated by specific motifs located in the flanking untranslated regions (UTRs) led us to consider the role of titin 5'-UTR in regulating its translational efficiency. Titin 5'-UTR is highly homologous between...

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Identifiers

PMID: 25264194
DOI: 10.1016/j.bbrc.2014.09.085
PMCID: PMC4250383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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