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Article

Fluorescence resonance energy transfer reports properties of syntaxin1a interaction with Munc18-1 in vivo.

The Journal of biological chemistry - 31 Dec 2004

Liu Jiang, Ernst Stephen A, Gladycheva Svetlana E, Lee Yue Ying F, Lentz Stephen I, Ho Chi S, Li Quanwen, Stuenkel Edward L

Abstract excerpt

Syntaxin1A, a neural-specific N-ethylmaleimide-sensitive factor attachment protein receptor protein essential to neurotransmitter release, in isolation forms a closed conformation with an N-terminal alpha-helix bundle folded upon the SNARE motif (H3 domain), thereby limiting interaction of the H3 domain with cognate SNAREs. Munc18-1, a neural-specific member of the Sec1/Munc18 protein family, binds to syntaxin1A,...

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Source

Identifiers

PMID: 15489225
DOI: 10.1074/jbc.M410024200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Fluorescence resonance energy transfer reports properties of syntaxin1a interaction with Munc18-1 in vivo.PMID 15489225Read ↗

Munc18-dependent and -independent clustering of syntaxin in the plasma membrane of cultured endocrine cells.Semantic proximity Read ↗

Conformational switch of syntaxin-1 controls synaptic vesicle fusion.Semantic proximity Read ↗

Control of fusion pore dynamics during exocytosis by Munc18.Semantic proximity Read ↗

Dynamic conformational changes in munc18 prevent syntaxin binding.Semantic proximity Read ↗

A gain-of-function mutant of Munc18-1 stimulates secretory granule recruitment and exocytosis and reveals a direct interaction of Munc18-1 with Rab3.Semantic proximity Read ↗

Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex.Semantic proximity Read ↗

Syntaxin/Munc18 interactions in the late events during vesicle fusion and release in exocytosis.Semantic proximity Read ↗

Munc18c interaction with syntaxin 4 monomers and SNARE complex intermediates in GLUT4 vesicle trafficking.Semantic proximity Read ↗

SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion.Semantic proximity Read ↗

Rescue of Munc18-1 and -2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells.Semantic proximity Read ↗

Syntaxin 1A inhibits CFTR chloride channels by means of domain-specific protein-protein interactions.Semantic proximity Read ↗

Munc18-1 induces conformational changes of syntaxin-1 in multiple intermediates for SNARE assembly.Semantic proximity Read ↗

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