Article
Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex.
Proceedings of the National Academy of Sciences of the United States of America - 28 Dec 2010
Rathore Shailendra S, Bend Eric G, Yu Haijia, Hammarlund Marc, Jorgensen Erik M, Shen Jingshi
Abstract excerpt
Intracellular membrane fusion is mediated by the concerted action of N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and Sec1/Munc18 (SM) proteins. During fusion, SM proteins bind the N-terminal peptide (N-peptide) motif of the SNARE subunit syntaxin, but the function of this interaction is unknown. Here, using FRET-based biochemical reconstitution and Caenorhabditis elegans genetics, we...
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