Article
Syntaxin 1A inhibits CFTR chloride channels by means of domain-specific protein-protein interactions.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1998
Naren A P, Quick M W, Collawn J F, Nelson D J, Kirk K L
Abstract excerpt
Previously we showed that the functional activity of the epithelial chloride channel that is encoded by the cystic fibrosis gene (CFTR) is reciprocally modulated by two components of the vesicle fusion machinery, syntaxin 1A and Munc-18. Here we report that syntaxin 1A inhibits CFTR chloride chan...
Topics
- Animals
- Antigens, Surface
- COS Cells
- Cystic Fibrosis Transmembrane Conductance Regulator
- Humans
- LLC-PK1 Cells
- Mutation
- Nerve Tissue Proteins
- Protein Binding
- Swine
- Syntaxin 1
- Xenopus