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Article

Control of fusion pore dynamics during exocytosis by Munc18.

Science (New York, N.Y.) - 2 Feb 2001

Fisher R J, Pevsner J, Burgoyne R D

Abstract excerpt

Intracellular membrane fusion is mediated by the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins. All vesicle transport steps also have an essential requirement for a member of the Sec1 protein family, including the neuronal Munc18-1 (also known as nSec1) in regulated exocytosis. Here, in adrenal chromaffin cells, we expressed a Munc18 mutant with reduced affinity for...

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Source

Identifiers

PMID: 11157167
DOI: 10.1126/science.291.5505.875

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Control of fusion pore dynamics during exocytosis by Munc18.PMID 11157167Read ↗

The functions of Munc18-1 in regulated exocytosis.Semantic proximity Read ↗

Syntaxin/Munc18 interactions in the late events during vesicle fusion and release in exocytosis.Semantic proximity Read ↗

Role of Munc18-1 in synaptic vesicle and large dense-core vesicle secretion.Semantic proximity Read ↗

Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions.Semantic proximity Read ↗

A gain-of-function mutant of Munc18-1 stimulates secretory granule recruitment and exocytosis and reveals a direct interaction of Munc18-1 with Rab3.Semantic proximity Read ↗

Munc18-1 tuning of vesicle merger and fusion pore properties.Semantic proximity Read ↗

Selective activation of cognate SNAREpins by Sec1/Munc18 proteins.Semantic proximity Read ↗

The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis.Semantic proximity Read ↗

Munc18-1 induces conformational changes of syntaxin-1 in multiple intermediates for SNARE assembly.Semantic proximity Read ↗

Conformational switch of syntaxin-1 controls synaptic vesicle fusion.Semantic proximity Read ↗

WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis.Semantic proximity Read ↗

Rescue of Munc18-1 and -2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells.Semantic proximity Read ↗

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