Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Munc18c interaction with syntaxin 4 monomers and SNARE complex intermediates in GLUT4 vesicle trafficking.

The Journal of biological chemistry - 1 Jun 2007

D'Andrea-Merrins Matthew, Chang Louise, Lam Alice D, Ernst Stephen A, Stuenkel Edward L

Abstract excerpt

In the process of insulin-stimulated GLUT4 vesicle exocytosis, Munc18c has been proposed to control SNARE complex formation by inactivating syntaxin 4 in a self-associated conformation. Using in vivo fluorescence resonance energy transfer in 3T3L1 adipocytes, co-immunoprecipitation, and in vitro...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipocytes
Share to Biological Transport, Active
Share to Cytoplasmic Vesicles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose Transporter Type 4

Share to Multiprotein Complexes

Share to Munc18 Proteins

Share to Qa-SNARE Proteins

Share to Qb-SNARE Proteins

Source

Identifiers

PMID: 17412693
DOI: 10.1074/jbc.M610818200

Genes

SNAP23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17412693-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Munc18c interaction with syntaxin 4 monomers and SNARE complex intermediates in GLUT4 vesicle trafficking.PMID 17412693Read ↗

Tyrosine phosphorylation of Munc18c on residue 521 abrogates binding to Syntaxin 4.Semantic proximity Read ↗

Discrimination of GLUT4 vesicle trafficking from fusion using a temperature-sensitive Munc18c mutant.Semantic proximity Read ↗

Fluorescence resonance energy transfer reports properties of syntaxin1a interaction with Munc18-1 in vivo.Semantic proximity Read ↗

WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis.Semantic proximity Read ↗

Munc18-1 induces conformational changes of syntaxin-1 in multiple intermediates for SNARE assembly.Semantic proximity Read ↗

Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes.Semantic proximity Read ↗

Syntaxin/Munc18 interactions in the late events during vesicle fusion and release in exocytosis.Semantic proximity Read ↗

Control of fusion pore dynamics during exocytosis by Munc18.Semantic proximity Read ↗

The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis.Semantic proximity Read ↗

A gain-of-function mutant of Munc18-1 stimulates secretory granule recruitment and exocytosis and reveals a direct interaction of Munc18-1 with Rab3.Semantic proximity Read ↗

Conformational switch of syntaxin-1 controls synaptic vesicle fusion.Semantic proximity Read ↗

Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.