Article
Conformational switch of syntaxin-1 controls synaptic vesicle fusion.
Science (New York, N.Y.) - 12 Sept 2008
Gerber Stefan H, Rah Jong-Cheol, Min Sang-Won, Liu Xinran, de Wit Heidi, Dulubova Irina, Meyer Alexander C, Rizo Josep, Arancillo Marife, Hammer Robert E, Verhage Matthijs, Rosenmund Christian, Südhof Thomas C
Abstract excerpt
During synaptic vesicle fusion, the soluble N-ethylmaleimide-sensitive factor-attachment protein receptor (SNARE) protein syntaxin-1 exhibits two conformations that both bind to Munc18-1: a "closed" conformation outside the SNARE complex and an "open" conformation in the SNARE complex. Although SNARE complexes containing open syntaxin-1 and Munc18-1 are essential for exocytosis, the function of closed syntaxin-1...
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