Article
Rescue of Munc18-1 and -2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells.
Molecular biology of the cell - 1 Dec 2009
Han Liping, Jiang Tiandan, Han Gayoung A, Malintan Nancy T, Xie Li, Wang Li, Tse Frederick W, Gaisano Herbert Y, Collins Brett M, Meunier Frederic A, Sugita Shuzo
Abstract excerpt
Munc18-1 binds to syntaxin-1A via two distinct sites referred to as the "closed" conformation and N terminus binding. The latter has been shown to stimulate soluble N-ethylmaleimide-sensitive factor attachment protein receptor-mediated exocytosis, whereas the former is believed to be inhibitory or dispensable. To precisely define the contributions of each binding mode, we have engineered Munc18-1/-2 double...
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