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Article

Syntaxin/Munc18 interactions in the late events during vesicle fusion and release in exocytosis.

The Journal of biological chemistry - 30 Jul 2004

Graham Margaret E, Barclay Jeff W, Burgoyne Robert D

Abstract excerpt

The SNARE proteins, syntaxin, SNAP-25, and VAMP, form part of the core machinery for membrane fusion during regulated exocytosis. Additional proteins are required to account for the speed, spatial restriction, and tight control of exocytosis and a key role is played by members of the Sec1/Munc18 family of proteins that have been implicated either in vesicle docking or fusion itself through their interactions with...

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Identifiers

PMID: 15175344
DOI: 10.1074/jbc.M400827200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Syntaxin/Munc18 interactions in the late events during vesicle fusion and release in exocytosis.PMID 15175344Read ↗

Control of fusion pore dynamics during exocytosis by Munc18.Semantic proximity Read ↗

The functions of Munc18-1 in regulated exocytosis.Semantic proximity Read ↗

Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions.Semantic proximity Read ↗

Conformational switch of syntaxin-1 controls synaptic vesicle fusion.Semantic proximity Read ↗

Munc18-1 tuning of vesicle merger and fusion pore properties.Semantic proximity Read ↗

A gain-of-function mutant of Munc18-1 stimulates secretory granule recruitment and exocytosis and reveals a direct interaction of Munc18-1 with Rab3.Semantic proximity Read ↗

Role of Munc18-1 in synaptic vesicle and large dense-core vesicle secretion.Semantic proximity Read ↗

Amisyn regulates exocytosis and fusion pore stability by both syntaxin-dependent and syntaxin-independent mechanisms.Semantic proximity Read ↗

Synaptotagmin-Ca2+ triggers two sequential steps in regulated exocytosis in rat PC12 cells: fusion pore opening and fusion pore dilation.Semantic proximity Read ↗

Munc18-1 induces conformational changes of syntaxin-1 in multiple intermediates for SNARE assembly.Semantic proximity Read ↗

Molecular analysis of SNAP-25 function in exocytosis.Semantic proximity Read ↗

Positively charged amino acids at the SNAP-25 C terminus determine fusion rates, fusion pore properties, and energetics of tight SNARE complex zippering.Semantic proximity Read ↗

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