Article
p53 Deficiency rescues neuronal apoptosis but not differentiation in DNA polymerase beta-deficient mice.
Molecular and cellular biology - 1 Nov 2004
Sugo Noriyuki, Niimi Naoko, Aratani Yasuaki, Takiguchi-Hayashi Keiko, Koyama Hideki
Abstract excerpt
In mammalian cells, DNA polymerase beta (Polbeta) functions in base excision repair. We have previously shown that Polbeta-deficient mice exhibit extensive neuronal cell death (apoptosis) in the developing nervous system and that the mice die immediately after birth. Here, we studied potential roles in the phenotype for p53, which has been implicated in DNA damage sensing, cell cycle arrest, and apoptosis. We...
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