Article
Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Jun 2008
Arbour Nicole, Vanderluit Jacqueline L, Le Grand J Nicole, Jahani-Asl Arezu, Ruzhynsky Vladimir A, Cheung Eric C C, Kelly Melissa A, MacKenzie Alexander E, Park David S, Opferman Joseph T, Slack Ruth S
Abstract excerpt
Despite the importance of Mcl-1, an anti-apoptotic Bcl-2 family member, in the regulation of apoptosis, little is known regarding its role in nervous system development and injury-induced neuronal cell death. Because germline deletion of Mcl-1 results in peri-implantation lethality, we address the function of Mcl-1 in the nervous system using two different conditional Mcl-1 mouse mutants in the developing nervous...
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