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Article

Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system.

The EMBO journal - 15 Nov 1996

Macleod K F, Hu Y, Jacks T

Abstract excerpt

Extensive apoptosis occurs in the nervous system of mouse embryos homozygous mutant for a targeted disruption of the retinoblastoma (Rb) gene. This cell death is present in both the central (CNS) and peripheral nervous systems (PNS) and is associated with abnormal S phase entry of normally post-m...

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Identifiers

PMID: 8947040
PMCID: PMC452439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-8947040-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system.PMID 8947040Read ↗

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