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Article

Decreased PARP-1 levels accelerate embryonic lethality but attenuate neuronal apoptosis in DNA polymerase beta-deficient mice.

Biochemical and biophysical research communications - 16 Mar 2007

Sugo Noriyuki, Niimi Naoko, Aratani Yasuaki, Masutani Mitsuko, Suzuki Hiroshi, Koyama Hideki

Abstract excerpt

In mammalian cells, DNA polymerase beta (Polbeta) and poly(ADP-ribose) polymerase-1 (PARP-1) have been implicated in base excision repair (BER) and single-strand break repair. Polbeta knockout mice exhibit extensive neuronal apoptosis during neurogenesis and die immediately after birth, while PARP-1 knockout mice are viable and display hypersensitivity to genotoxic agents and genomic instability. Although...

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Identifiers

PMID: 17257586
DOI: 10.1016/j.bbrc.2006.12.230

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