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Article

Nuclear Factor-κB Modulates the p53 Response in Neurons Exposed to DNA Damage

24 Mar 2004

Abstract excerpt

Previous studies have shown that DNA damage-evoked death of primary cortical neurons occurs in a p53 and cyclin-dependent kinase-dependent (CDK) manner. The manner by which these signals modulate death is unclear. Nuclear factor-kappaB (NF-kappaB) is a group of transcription factors that potentially interact with these pathways. Presently, we show that NF-kappaB is activated shortly after induction of DNA damage...

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PMID: 15044535
DOI: 10.1523/jneurosci.0155-04.2004

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