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Article

Genetic interaction between DNA polymerase beta and DNA-PKcs in embryogenesis and neurogenesis.

Cell death and differentiation - 1 Feb 2005

Niimi N, Sugo N, Aratani Y, Koyama H

Abstract excerpt

DNA polymerase beta (Polbeta) has been implicated in base excision repair. Polbeta knockout mice exhibit apoptosis in postmitotic neuronal cells and die at birth. Also, mice deficient in nonhomologous end-joining (NHEJ), a major pathway for DNA double-strand break repair, cause massive neuronal apoptosis. Severe combined immunodeficiency (SCID) mice have a mutation in the gene encoding DNA-dependent protein...

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Identifiers

PMID: 15647757
DOI: 10.1038/sj.cdd.4401543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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