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Decreased mutant frequency in embryonic brain of DNA polymerase beta null mice.

Mutagenesis - 1 Jan 2006

Niimi Naoko, Sugo Noriyuki, Aratani Yasuaki, Gondo Yoichi, Katsuki Motoya, Koyama Hideki

Abstract excerpt

DNA polymerase beta (Polbeta) knockout mouse embryos exhibit extensive apoptosis in postmitotic neuronal cells and die immediately after birth. In contrast, no apoptosis has been observed in other tissues as well as liver in the mutant embryos. To study the relationship of Polbeta deficiency and mutagenesis during development and neurogenesis, we examined spontaneous mutations in Polbeta null (Polbeta-/-) and...

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Identifiers

PMID: 16399847
DOI: 10.1093/mutage/gei074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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