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Article

Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells.

Cell - 1 Dec 2006

Cang Yong, Zhang Jianxuan, Nicholas Sally A, Bastien Jayson, Li Baojie, Zhou Pengbo, Goff Stephen P

Abstract excerpt

DDB1, a component of the Cul4 ubiquitin ligase complex, promotes protein ubiquitination in diverse cellular functions, including nuclear excision repair, regulation of the cell cycle, and DNA replication. To investigate its physiological significance, we generated mice with null and floxed alleles of the DDB1 gene. Here we report that null mutation of DDB1 caused early embryonic lethality, while conditional...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17129780
DOI: 10.1016/j.cell.2006.09.045

Genes

DDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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