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Article

ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse.

Molecular and cellular biology - 1 Nov 2004

Jörnvall Henrik, Reissmann Eva, Andersson Olov, Mehrkash Mehrnaz, Ibáñez Carlos F

Abstract excerpt

Mesendoderm formation and left-right patterning during vertebrate development depend upon selected members of the transforming growth factor beta superfamily, particularly Nodal and Nodal-related ligands. Two type I serine/threonine kinase receptors have been identified for Nodal, ALK4 and ALK7. Mouse embryos lacking ALK4 fail to produce mesendoderm and die shortly after gastrulation, resembling the phenotype of...

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Identifiers

PMID: 15485907
DOI: 10.1128/MCB.24.21.9383-9389.2004
PMCID: PMC522223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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