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Article

Loss of Cited2 causes congenital heart disease by perturbing left–right patterning of the body axis

24 Dec 2010

Abstract excerpt

Cited2 is a transcriptional coactivator that is required for normal development of the embryo and placenta. Cited2-null mice die during gestation with fully penetrant heart defects and partially penetrant laterality defects. The laterality defects occur due to the loss of Nodal expression in the left lateral plate mesoderm (LPM). The cause of the heart defects that arise independently of laterality defects is...

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PMID: 21224256
DOI: 10.1093/hmg/ddq554

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