Article
Rotatin is a novel gene required for axial rotation and left-right specification in mouse embryos.
Mechanisms of development - 1 Apr 2002
Faisst Anja M, Alvarez-Bolado Gonzalo, Treichel Dieter, Gruss Peter
Abstract excerpt
The genetic cascade that governs left-right (L-R) specification is starting to be elucidated. In the mouse, the lateral asymmetry of the body axis is revealed first by the asymmetric expression of nodal, lefty2 and pitx2 in the left lateral plate mesoderm of the neurulating embryo. Here we describe a novel gene, rotatin, essential for the correct expression of the key L-R specification genes nodal, lefty and...
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