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Article

Left-right patterning of the mouse lateral plate requires nodal produced in the node.

Developmental biology - 1 Apr 2003

Saijoh Yukio, Oki Shinya, Ohishi Sachiko, Hamada Hiroshi

Abstract excerpt

Initial determination of left-right (L-R) polarity in mammalian embryos takes place in the node. However, it is not known how asymmetric signals are generated in the node and transferred to the lateral plate mesoderm (LPM). Mice homozygous for a hypomorphic Nodal allele (Nodal(neo)) were generated and found to exhibit L-R defects, including right isomerism. Although the mutant embryos express Nodal at...

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Source

Identifiers

PMID: 12654299
DOI: 10.1016/s0012-1606(02)00121-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Left-right patterning of the mouse lateral plate requires nodal produced in the node.PMID 12654299Read ↗

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Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish.Semantic proximity Read ↗

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