Roles for fgf8 signaling in left-right patterning of the visceral organs and craniofacial skeleton.

Abstract excerpt

Laterality is fundamental to the vertebrate body plan. Here, we investigate the roles of fgf8 signaling in LR patterning of the zebrafish embryo. We find that fgf8 is required for proper asymmetric development of the brain, heart and gut. When fgf8 is absent, nodal signaling is randomized in the lateral plate mesoderm, leading to aberrant LR orientation of the brain and visceral organs. We also show that fgf8 is...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Branchial Region
• Share to Facial Bones
• Share to Fibroblast Growth Factor 8