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Article

Notch signaling regulates left-right asymmetry determination by inducing Nodal expression.

Genes & development - 15 May 2003

Krebs Luke T, Iwai Naomi, Nonaka Shigenori, Welsh Ian C, Lan Yu, Jiang Rulang, Saijoh Yukio, O'Brien Timothy P, Hamada Hiroshi, Gridley Thomas

Abstract excerpt

Generation of left-right asymmetry is an integral part of the establishment of the vertebrate body plan. Here we show that the Notch signaling pathway plays a primary role in the establishment of left-right asymmetry in mice by directly regulating expression of the Nodal gene. Embryos mutant for the Notch ligand Dll1 or doubly mutant for the Notch1 and Notch2 receptors exhibit multiple defects in left-right...

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Source

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Identifiers

PMID: 12730124
DOI: 10.1101/gad.1084703
PMCID: PMC196059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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