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Article

Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success.

The Journal of experimental medicine - 18 Oct 2004

Hiby Susan E, Walker James J, O'shaughnessy Kevin M, Redman Christopher W G, Carrington Mary, Trowsdale John, Moffett Ashley

Abstract excerpt

Preeclampsia is a serious complication of pregnancy in which the fetus receives an inadequate supply of blood due to failure of trophoblast invasion. There is evidence that the condition has an immunological basis. The only known polymorphic histocompatibility antigens on the fetal trophoblast are HLA-C molecules. We tested the idea that recognition of these molecules by killer immunoglobulin receptors (KIRs) on...

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Identifiers

PMID: 15477349
DOI: 10.1084/jem.20041214
PMCID: PMC2211839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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