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Article

Maternal uterine NK cell-activating receptor KIR2DS1 enhances placentation.

The Journal of clinical investigation - 1 Oct 2013

Xiong Shiqiu, Sharkey Andrew M, Kennedy Philippa R, Gardner Lucy, Farrell Lydia E, Chazara Olympe, Bauer Julien, Hiby Susan E, Colucci Francesco, Moffett Ashley

Abstract excerpt

Reduced trophoblast invasion and vascular conversion in decidua are thought to be the primary defect of common pregnancy disorders including preeclampsia and fetal growth restriction. Genetic studies suggest these conditions are linked to combinations of polymorphic killer cell Ig-like receptor (KIR) genes expressed by maternal decidual NK cells (dNK) and HLA-C genes expressed by fetal trophoblast. Inhibitory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24091323
DOI: 10.1172/JCI68991
PMCID: PMC4382274

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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