Immunity at maternal–fetal interface: KIR / HLA (Allo)recognition*

doi:10.1111/imr.13087

Article

Immunity at maternal–fetal interface: KIR / HLA (Allo)recognition*

24 May 2022

Abstract excerpt

Both KIR and HLA are the most variable gene families in the human genome. The recognition of the semi-allogeneic embryo-derived trophoblasts by maternal decidual NK (dNK) cells is essential for the establishment of the functional placenta. This recognition is based on the KIR-HLA interactions and trophoblast expresses a specific HLA profile that constitutes classical polymorphic HLA-C and non-classical...

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