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Maternal-Fetal HLA Compatibility in Uncomplicated and Preeclamptic Naturally Conceived Pregnancies

13 May 2021

Abstract excerpt

Introduction: In pregnancy, the mother and fetus differ in HLA antigens, and yet the maternal immune system generally tolerates the fetus. KIR receptors expressed by maternal uterine NK cells at the maternal-fetal interface directly interact with HLA-C on extravillous trophoblast cells for optimal placental development. In this study, we aimed to determine whether there is a preferential selection for HLA...

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PMID: 34054856
DOI: 10.3389/fimmu.2021.673131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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