Killer immunoglobulin-like receptors (KIRs) and HLA-C allorecognition patterns implicative of dominant activation of natural killer cells contribute to recurrent miscarriages

Abstract excerpt

BACKGROUND: Decidual natural killer (NK) cells play key developmental roles at the feto-maternal interface. Individual differences in NK-cell interactions are dependent on the combinations of variable killer immunoglobulin-like receptor (KIR) and HLA class-I gene products. As different receptor-ligand interactions may result in altered NK-cell-mediated immunity against pathogens, it is proposed that the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Ectopic Pregnancy Diagnosis and Management
• Share to Immune Cell Function and Interaction
• Share to Reproductive System and Pregnancy