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Article

Structural variation in human apolipoprotein E3 and E4: secondary structure, tertiary structure, and size distribution.

Biophysical journal - 1 Jan 2005

Chou Chi-Yuan, Lin Yi-Ling, Huang Yu-Chyi, Sheu Sheh-Yi, Lin Ta-Hsien, Tsay Huey-Jen, Chang Gu-Gang, Shiao Ming-Shi

Abstract excerpt

Human apolipoprotein E (apoE) is a 299-amino-acid protein with a molecular weight of 34 kDa. The difference between the apoE3 and apoE4 isoforms is a single residue substitution involving a Cys-Arg replacement at residue 112. ApoE4 is positively associated with atherosclerosis and late-onset and sporadic Alzheimer's disease (AD). ApoE4 and its C-terminal truncated fragments have been found in the senile plaques...

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Identifiers

PMID: 15475580
DOI: 10.1529/biophysj.104.046813
PMCID: PMC1305022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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